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  • Sleep and Sleep Disorders in Chronic Users of Zopiclone and . . .
    To examine polysomnographic parameters and sleep diary data, as well as the prevalence of sleep apnea and periodic limb movement disorder (PLMD) in older chronic users of zopiclone compared with aged-matched drug-free patients with insomnia and good sleepers
  • Dose-Response Effects of Zopiclone on Night Sleep and on . . .
    Degree of daytime somnolence was assessed during day 1 by means of a multiple sleep latency test (MSLT) and performance evaluation was carried out during night 2 (0000 h) and day 2 (800 hand 1200 h) by means of a battery of four tests, NREM sleep stages 3 and 4 increased significantly after 3 75 mg and 7 5 mg zopiclone (p < 0 05), No
  • [Effects of zopiclone on sleep, daytime somnolence and . . .
    Sleep continuity was not modified, except for a reduction of the number of night awakenings NREM sleep stage 1 was reduced and stage 2 was increased (in duration but not in percentage) with Zopiclone 3 75 and 7 5 mg NREM sleep stages 3 and 4 were increased with Zopiclone 3 75 mg only
  • Zopiclone to treat insomnia in older adults: A systematic review
    Overall, the studies suggest that zopiclone is effective to treat insomnia by reducing sleep latency, nocturnal awakenings and wake time after sleep onset while increasing total sleep time, with probable effects on sleep architecture
  • Randomized Trial on the Effects of High-Dose Zopiclone on OSA . . .
    Studies indicate that standard doses of hypnotics reduce or do not change the apnea-hypopnea index (AHI) or pharyngeal muscle activity A 1-month trial of nightly zopiclone (7 5 mg) modestly reduced the AHI vs baseline without changing other sleep parameters or next-day sleepiness
  • Sleep and Sleep Disorders in Chronic Users of Zopiclone and . . .
    To examine polysomnographic parameters and sleep diary data, as well as the prevalence of sleep apnea and periodic limb movement disorder (PLMD) in older chronic users of zopiclone compared with aged-matched drug-free patients with insomnia and good sleepers
  • Zopiclone versus placebo for short-term treatment of insomnia . . .
    After six nights of intervention, patients receiving zopiclone reported significantly better sleep quality as compared with patients receiving placebo, adjusted for baseline sleep quality





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