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  • A systematic review of interleukin-2-based immunotherapies in . . .
    Thus, numerous IL-2-based biologic agents with improved bias or delivery towards effector immune cells or Treg cells have been developed This study systematically reviews clinical results of improved IL-2-based compounds
  • Rethinking Oncologic Treatment Strategies with Interleukin-2
    A first-in-human phase 1 2 dose escalation and dose expansion study (NCT05081609) is ongoing evaluating TransCon IL-2 β γ alone or in combination with pembrolizumab, standard-of-care chemotherapy, or a TLR7 8 agonist in patients with locally advanced or metastatic solid tumors
  • Harnessing IL-2 for immunotherapy against cancer and chronic . . .
    Many studies on engineering IL-2 as a combined therapy with PD-1-mediated immunotherapy have been conducted In this review, considering the heterogeneity of exhausted CD8 + T cells, we first
  • Prospects of IL-2 in Cancer Immunotherapy - PMC
    Recent studies showed that immunization with combination of IL-2 and an altered peptide ligand derived from gp100 (melanoma associated protein) has better overall clinical response In this case, the progression-free survival was of relatively longer duration than IL-2 treatment alone
  • Reigniting hope in cancer treatment: the promise and pitfalls . . .
    Therefore, IL-2 has been used in combination with other immunotherapies, such as checkpoint inhibitors, to optimize anti-tumor immune responses For example, high-dose IL-2, combined with ipilimumab (an anti-CTLA-4 antibody), has shown promise by inducing durable responses in patients with metastatic melanoma However, combination
  • Combining IL-2-based immunotherapy with commensal probiotics . . .
    In this study, we aim to investigate the enhancing effect of Akkermansia muciniphila (AKK), a beneficial commensal microbe receiving considerable attentions, on the antitumor efficacy of IL-2 and explore the underlying molecular mechanism
  • Combining IL-2-based immunotherapy with commensal probiotics . . .
    In this study, we aim to investigate the enhancing effect of Akkermansia muciniphila (AKK), a beneficial commensal microbe receiving considerable attentions, on the antitumor efficacy of IL-2 and explore the underlying molecular mechanism





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