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  • Mechanism of action of anticonvulsants | Neurology
    Phenytoin facilitated GABA uptake to a lesser extent than did pentobarbital, but also increased the uptake of glutamate This suggests that these drugs may limit the propagation of seizures through the balance of excitatory glutamate pathways and inhibitory GABA and norepinephrine pathways
  • Ketosis and brain handling of glutamate, glutamine, and GABA
    We hypothesize that one mechanism of the anti-epileptic effect of the ketogenic diet is to alter brain handling of glutamate According to this formulation, in ketotic brain astrocyte metabolism is more active, resulting in enhanced conversion of glutamate to glutamine
  • Glutamate and GABA synthesis, release, transport and metabolism as . . .
    Given the role that these two neurotransmitters play in normal and abnormal neurotransmission, it is important to consider the processes whereby they are regulated This brief review is focused entirely on the metabolic aspects of glutamate and GABA synthesis and neurotransmission
  • The effect of phenytoin on glutamate and GABA transport
    Phenytoin was observed to inhibit competitively the sodium dependent high affinity synaptosomal transport of both glutamate (Glu) and gamma-aminobutyric acid (GABA) with Ki values of 66 + - 10 and 185 + - 65 microM, respectively
  • How Can Drugs Affect Glutamate? – Troscriptions®
    In today’s article, we will look at some of the main classes of drugs that affect glutamate levels and signaling, as well as their mechanisms, applications, and potential implications of their use
  • Describes the mechanisms with which drugs affect glutamate . . .
    Serotonin reuptake inhibitors and benzodiazepines are evidence-based pharmacological treatments for Anxiety Disorders targeting serotonin and GABAergic systems, respectively Although clearly
  • The Pharmacology of Ketotifen - CHEST
    Both compounds inhibit the histamine skin reaction and when given together show an additive effect In the allergen test, however, ketotifen alone is effective and the addition of clemastine does not produce any greater inhibition
  • Influence of glutamate and GABA transport on brain excitatory . . .
    Herein, we review the synthesis, release, and signaling of the principle CNS excitatory and inhibitory neurotransmitters (namely glutamate and GABA, respectively) and discuss the capacity of glutamate and GABA transporters to modulate release and uptake of neurotransmitter, as well as neural network activity
  • Milestone Review: Metabolic dynamics of glutamate and GABA . . . - PubMed
    Recent advances on cellular glutamate and GABA homeostasis are reviewed in the context of brain pathology, including glutamate toxicity and neurodegeneration Finally, we consider how pathological astrocyte metabolism may serve as a potential target of metabolic intervention





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