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mutilated    音标拼音: [mj'utəl,etəd] [mj'utəl,etɪd]
mutilated
adj 1: having a part of the body crippled or disabled [synonym:
{maimed}, {mutilated}]

mutilated \mutilated\ adj.
1. badly injured, perhaps with amputation or permanent
disfigurement; as, mutilated victims of the rocket attack.

Syn: maimed.
[WordNet 1.5]

3. damaged, often deliberately; -- of compositions; as, a
mutilated text. Opposite of {undamaged} or {intact}.

Syn: mangled, mutilated.
[WordNet 1.5]


Mutilate \Mu"ti*late\, v. t. [imp. & p. p. {Mutilated}; p. pr. &
vb. n. {Mutilating}.]
1. To cut off or remove a limb or essential part of; to maim;
to cripple; to disfigure; to hack; as, to mutilate the
body, a statue, etc.
[1913 Webster]

2. To destroy or remove a material part of, so as to render
imperfect; as, to mutilate the orations of Cicero.
[1913 Webster]

Among the mutilated poets of antiquity, there is
none whose fragments are so beautiful as those of
Sappho. --Addison.
[1913 Webster]

{Mutilated gear}, {Mutilated wheel} (Mach.), a gear wheel
from a portion of whose periphery the cogs are omitted. It
is used for giving intermittent movements.
[1913 Webster]

92 Moby Thesaurus words for "mutilated":
aggravated, bandy, bandy-legged, blemished, bloated, bowlegged,
broken, burned, burst, busted, butchered, castrated, checked,
chipped, cleft, cloven, club-footed, cracked, crazed, cut,
cut short, damaged, defaced, deformed, deteriorated, disfigured,
docked, dwarfed, embittered, exacerbated, flatfooted, garbled,
grotesque, harmed, hashed, hurt, ill-made, ill-proportioned,
ill-shaped, impaired, imperfect, in bits, in pieces, in shards,
in shreds, injured, irritated, knock-kneed, lacerate, lacerated,
lopped, malformed, mangled, marred, misbegotten, misproportioned,
misshapen, monstrous, out of shape, pigeon-toed, pug-nosed,
quartered, rachitic, ragged, rent, rickety, riven, ruptured,
scalded, scorched, severed, shattered, shredded, simous, slashed,
slit, smashed, snub-nosed, splintered, split, sprung, stumpy,
swaybacked, talipedic, tattered, the worse for, torn, truncated,
weakened, worse, worse off, worsened


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  • Angioedema - EMCrit Project
    tranexamic acid Physiology: Tranexamic acid inhibits the conversion of plasminogen into plasmin, which is a critical step involved in amplification of kallikrein activation Theoretically, this should be beneficial in any form of bradykinin-mediated angioedema Evidence: Tranexamic acid has been used for hereditary angioedema for decades
  • Tranexamic Acid for the Emergency Treatment of Angiotensin-Converting . . .
    Tranexamic acid (TXA) is used as an alternative therapy for long-term prophylaxis in HAE by inhibiting the activation of plasminogen to plasmin and thus decreasing bradykinin production The role of TXA in the acute treatment of bradykinin-mediated angioedema is less clear
  • Tranexamic acid for ACE inhibitor induced angioedema
    Tranexamic acid (TXA) is an antifibrinolytic agent which inhibits conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation Tranexamic acid is used in prophylactic management of hereditary angioedema; however, evidence for TXA in angiotensin converting enzym …
  • Tranexamic acid for angioedema
    Although tranexamic acid is not formally approved to treat any type of angioedema, it has been used off-label to prevent or treat swelling attacks in people with hereditary angioedema (HAE) While tranexamic acid may have some efficacy for HAE, it’s generally considered to be much less effective than other approved medications, so it is usually only given as a first-line treatment if other
  • The use of intravenous tranexamic acid for patients with angiotensin . . .
    ACEI-induced angioedema and hereditary angioedema are both associated with increased circulating bradykinin 2 However, there is no clear evidence for using approved agents for hereditary angioedema in ACEI-induced angioedema 4 By inhibiting the activation of plasmin, TXA has the potential to inhibit the downstream pathway of bradykinin
  • What is the evidence regarding tranexamic acid use in angioedema? What . . .
    According to societal guidelines, tranexamic acid (TA) is not recommended for acute treatment of hereditary angioedema due to minimal benefit, but it may be considered for long-term prophylaxis when first-line options are unavailable or contraindicated In idiopathic and bradykinin-mediated angioedema, including angiotensin-converting enzyme inhibitor (ACE-i)-induced cases, limited evidence
  • Tranexamic Acid for the Emergency Treatment of Angiotensin . . . - Cureus
    transmission, volume-associated circulatory injuries, and worsening angioedema symptoms [6,13] Tranexamic acid (TXA) is used as an alternative therapy for long-term prophylaxis in HAE by inhibiting the activation of plasminogen to plasmin and thus decreasing bradykinin production The role of TXA in the
  • The use of tranexamic acid for on‐demand and prophylactic treatment of . . .
    The following search terms were used: “hereditary angioedema” OR “hereditary angio-neurotic edema” AND “tranexamic acid ” The main searches were complemented by searching the Cochrane Library; however, no additional studies were identified Searches were also performed on Embase to identify additional studies not found in PubMed
  • :: Clinical and Experimental Emergency Medicine
    Given the prevalent use of ACEIs, there is an urgent clinical need for a rapidly effective therapeutic intervention for severe ACEI-IA The successful use of tranexamic acid (TXA) for the prophylaxis of acquired angioedema was first reported in an emergency setting by Beauchene et al in 2018 This review aims to investigate the efficacy of TXA
  • Tranexamic acid for angiotensin-converting enzyme inhibitor–induced . . .
    An additional clinical study evaluated TXA use as a maintenance treatment for nonhistaminergic angioedema in 37 patients, of which 18 were diagnosed with HAE and 19 were diagnosed with idiopathic angioedema These patients also did not respond to antihistaminic treatment (even at high doses) and complement treatment was not explored





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